Michelle Yu, MD, PhD

Assistant Professor

I am a Pulmonary and Critical Care Physician-Scientist. My clinical and research specialties are in Cystic Fibrosis lung infection and inflammation. I am the Principal Investigator of a basic science laboratory, and I serve as the Associate Program director of the UCSF Adult Cystic Fibrosis Center. I attend regularly in the ICUs at Parnassus and Mount Zion and am passionate about improving medical education particularly during COVID when our learners have faced unforeseen challenges.
Education
07/2018 - Pulmonary and Critical Care Fellowship, UCSF
07/2014 - Internal Medicine Residency, Brigham and Women's Hospital
MD, PhD, 06/2011 - Biophysics and Physiology, Albert Einstein College of Medicine
B.A., 06/2003 - Chemistry and Physics, Harvard University
Publications

  1. Yu MA, Banta AB, Ward RD, Prasad NK, Kwon MS, Rosenberg OS, Peters JM. Investigating Pseudomonas aeruginosa Gene Function During Pathogenesis Using Mobile-CRISPRi. Methods in molecular biology (Clifton, N.J.) 2024. PMID: 37819512


  2. Finbloom JA, Raghavan P, Kwon M, Kharbikar BN, Yu MA, Desai TA. Codelivery of synergistic antimicrobials with polyelectrolyte nanocomplexes to treat bacterial biofilms and lung infections. Science advances 2023. PMID: 36662850


  3. Al Alam D, Ballard PL, Jourdan Le Saux C, Ingram JL, Mariani T, Moore NS, Weiss DJ, Yu M. Human Fetal Tissue Regulation: Impact on Pediatric and Adult Respiratory-Related Research. Annals of the American Thoracic Society 2020. PMID: 33252996


  4. Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM. Antibiotic Adverse Reactions in Adult Cystic Fibrosis Patients. The journal of allergy and clinical immunology. In practice 2020. PMID: 32673878


  5. Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. The Journal of clinical investigation 2020. PMID: 31961827


  6. Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM. Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers. 2020. PMID: 32123733


  7. Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS. Modulating pathogenesis with Mobile-CRISPRi. Journal of bacteriology 2019. PMID: 31481541


  8. Yu MA, Egawa T, Shinzawa-Itoh K, Yoshikawa S, Guallar V, Yeh SR, Rousseau DL, Gerfen GJ. Two tyrosyl radicals stabilize high oxidation states in cytochrome C oxidase for efficient energy conservation and proton translocation. Volume 134 of Issue 10. 2012. PMID: 22296274


  9. Yu MA, Egawa T, Shinzawa-Itoh K, Yoshikawa S, Yeh SR, Rousseau DL, Gerfen GJ. Radical formation in cytochrome c oxidase. Volume 1807 of Issue 10. Biochimica et biophysica acta 2011. PMID: 21718686


  10. Egawa T, Ganesan K, Lin MT, Yu MA, Hosler JP, Yeh SR, Rousseau DL, Gennis RB. Differential effects of glutamate-286 mutations in the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo(3) ubiquinol oxidase from Escherichia coli. Volume 1807 of Issue 10. Biochimica et biophysica acta 2011. PMID: 21684251